As a cohort study of 106 US hospitals between 09/2018 and 01/2019 has shown, it is primarily important to check whether there really is a penicillin allergy at the time of the disease. In most cases, the allergy was already present some time ago and may have already disappeared. fter alternative testing with 1) ß-lactam antibiotic alternatives, such as macrolides, sulphonamides, tetracyclines, clindamycin and linezolid, 2) narrow-spectrum ß-lactam antibiotics, such as 1st/2nd generation cephalosporins and penicillins, and 3) other ß-lactams, such as aztreonam, monobactam, carbapenem and 3rd /4th generation cephalosporins, it was found that most patients with penicillin allergy were treated with ß-lactam alternative antibiotics, in particular clindamycins and aztreonam. For urogenital tract infections before surgery, with non-ß-lactam antibiotics. As suspected, the alternative treatment to penicillin is sometimes not as effective and clindamycin in particular has been shown to increase the risk of a clostidium difficile infection. It remains important to check the history of penicillin allergy and talk to the patient about the symptoms of the suspected allergy.
To what extent is penicillin allergy present and what alternative antibiotic treatment is possible?
Jul 16, 2020 | Health