It is useful to combine in vitro testing and in silico modelling to predict and understand the in vivo performance of formulations that improve bioavailability, resulting in a successful in vivo test for belinostat. The key factor for in vivo performance was determined to be dissolution in the stomach prior to transit in the proximal small intestine, as evidenced by in vitro data and in silico predictions.
Formulations that enhance bioavailability
Aug 25, 2020 | Manufacturing Process