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In the following you will find news from Polypharma Technologies & Sciences GmbH and the pharmaceutical industry.
Terbinafine 250mg tablet
Polypharma has developed a Terbinafine 250mg tablet. Terbinafine is an antimycotic and is the most common medication for skin and foot fungus.
Higher dosage of dulaglutide safe and effective in type 2 diabetes
The AWARD-11 study demonstrates that people with type 2 diabetes receiving a higher weekly dose of 3mg and/or 4.5mg instead of 0.75mg and 1.5mg administered by subcutaneous injections would see an improvement in blood glucose levels and weight loss. https://www.gelbe-liste.de/diabetologie/dulaglutid-typ2-diabetes
Study on the curative therapy of type 1 diabetes
In the treatment of long-term type 1 diabetes patients, the stimulation (induction) or restoration of immune tolerance is very important. In a first clinical study, tolerogenic dendritic cells (tolDC) with proinsulin peptide were administered as two intradermal injection series as a basic or booster vaccination at intervals of one month. The most important observation: There were no signs of systemic immunosuppression, no induction of insulin allergy, no disruption of insulin therapy and no...
Carbon-hydrogen bonds can now also be functionalised
After almost 25 years of work, chemists at the University of Berkeley have now succeeded in opening the least reactive C-H bonds using a newly developed catalyst and replacing them with a boron compound. Because the primary C-H bond of the terminal methyl group (CH3) - typically at the end or beginning of a molecule - has been replaced by a boron compound, it can easily be replaced by more complex chemical groups. For example, chemicals of plant or animal origin with antibiotic effects could...
Medicines produced by 3D printer
Research using 3D printers is entering its next phase. Research is being carried out into how tablets can be produced in the future using 3D printing. Here the starting substances for the medicines are mixed and melted in a pharmaceutical melt extruder and processed into filaments. The filaments can then be melted a second time in the 3D printer and printed. https://www.medica.de/de/News/Archiv/Arzneimittel_aus_dem_3D-Drucker...
Videoconference calls
Polypharma is now equipped with a video conference call system. We would like to continue our production support service for validation batches. Even though we are currently unable to undertake any business trips for this purpose, we are still personally available for you. If you have any questions about the equipment required in the production plant, please contact us. Contact
Learning curves in the current clinical biosimilar development
Many biosimilar developers need to think outside the box when structuring their clinical trials. As an example, one could discuss with a supervisor whether it is insufficient to investigate only one indication in the comparative efficacy study and rely on extrapolation for the remaining indications....
Reduction of concomitant diseases in stable coronary heart disease and diabetes mellitus
In a COMPASS study (Cardiovascular Outcomes for People Using Anticoagulation Strategies), taking 100mg of aspirin and 2.5mg of rivaroxaban twice daily demonstrated that the risk of myocardial infarction or stroke was significantly reduced. Cardiovascular mortality and all-cause mortality were also reduced. In patients with diabetes who have a higher risk of mortality, their absolute risk reduction is three times lower than in patients without diabetes....
Dapagliflozin tablets for type 2 diabetes
Dapagliflozin is the first molecule in the class of SGLT2 inhibitors to be marketed in France alone or in combination with metformin. Studies show that this oral antidiabetic reduces the morbidity and mortality of type 2 diabetics and helps prevent hospitalisation for heart failure....
Increase of patient satisfaction
Complex applicators, such as those found particularly in the pharmaceutical sector, are perceived as a challenge by many users. In the meantime, in addition to the package insert, training videos, personal explanations and the use of a training video stored by means of QR codes can also be helpful. pharmind 2020, No. 4, page 518
Polypharma
Technologies & Sciences GmbH
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20457 Hamburg
Germany
+49 (0)40 37 480 3-0
info[at]polypharma.de